Thirty-three-year-old Danielle Griffin of Anchorage on Sunday was ejected from the motorcycle near Mile 11 into a trailer being towed by semi driver David McDonald.
She was transported by helicopter to Providence Medical Center.
Troopers say her husband, 38-year-old Chad Griffin, was driving north and the semi was headed south, pulling two trailers.
Griffin tried to pass northbound vehicles and lost control of the motorcycle.
Danielle Griffin was ejected and struck the rear of the second trailer.
Troopers, Anchorage police and representatives of the National Parks Service responded.